I have a massive bilster now what?

Pop it with a needle, drain it, let it dry, slap a bandage and some tape on it.

Only a quarter?  Is there blood yet?  When there's blood, then it's decent. 

I get blisters regardless of socks and Body Glide, sometimes.

Mostly, they just gotta heal on their own, not much else you can do.  Within about 5-7 days, though, you'll be as good as new, generally speaking. 

Cool, nobody's said it yet:

Suck it up, buttercup!

Seriously, prior to my first tri a couple of weeks ago, I tried running w/out socks so I could do same during the bike/run portions of the race.  My feet didn't want to cooperate and I managed to get blisters on both soles.  Fast forward to race day and the issue was still there, albeit not as pronounced.  I mentioned to the guys doing the tri with me that I wanted to use socks due to the blister issue...they laughed and said the blisters would heal and I should "suck it up."  So I did and with a little talc in my shoes for good measure, things went great.  I developed a very small blister on my right foot sole, but that was it and it wasn't painful at all.

Good luck!