Orthotics w/ support shoe or neutral shoe??

I'm assuming that you're talking about custom orthotics that have been made to fit your feet.  I'm pretty sure that you're going to want to wear them with a neutral shoe.  They should provide the support you need.  And yes, you can hurt yourself by providing too much support/control.

I have had custom orthotics for almost 10 years and had always worn the same shoe, a Saucony stability shoe, the Shadow 6000.  I thought it was time to try some newer technology and had the same question as you.  I was told by the shoe fit expert at Road Runner Sports to stay with a stability shoe.  They recommended Brooks Adrenaline GTS and Saucony Grid Trigon Guide and I have been wearing both with no problems.    

The way it was explained to me is that custom orthotics correct to get you as close to neutral as possible. If you add a stabilizing shoe that is also correcting, that creates problems.

Bottom line of course, if you are already running in a motion correction shoe with orthotics and you aren't having any problems I'd stick with it. But if you're switiching to an orthotic for the first time, I'd go with a neautral shoe.

I had a bogus gait analysis in April of 2006 and not long after I developed achilles tendonitis and some bursitis in my hip that is still giving me problems. I've spent $1000's on treatment. The right shoes are critical if you have biomechanical issues.

I switched to an appropriate motion correction shoe and I'm getting better. I got the orthotics because I had 3 pairs of expensive neutral shoes and I didn't want to use them to kick around town. So now I alternate between neutral shoes with orthotics and the MC shoes.

Have you ever had a Footmaxx study or similar test? I LIT that thing up as a severe pronator, but the Brooks Adrenaline (or the Glycerine with orthotics) seem to be helping me.