Subject: RE: Run your azz off in July Ghoulies!!!My experiment: I'm testing a new hypothesis dealing with basic renal physiology. The current belief is that the little units inside a kidney (nephrons ) work individually from one another and self regulate their own blood flow which then basically determines what the kidney is filtering/how much is being filters/how much urine to make/etc. My project is basically challenging this: we say that the nephrons actually "talk" to one another (for lack of a better word ) and that this cross talk then determines how a group of nephrons function. The kidney is intimately involved in blood pressure regulation so I am using a laser that measures blood flow in specific regions of interest and seeing how changing blood pressure (low-high ) and using ACE inhibitors (captopril, ramopril, all the "pril" drugs ) affects the blood flow in the regions of interest. Our idea is the regions of interest that are directly adjacent to one another should be more alike on another than ones that are not adjacent--adjacent meaning that there is crosstalk occuring and should be more similar. So basically I am imaging the kidney and taking a whole bunch of measurements while reducing blood pressure down to 65mmHg and bringing it up to about 120mmHg. ^^Does it make sense? Prob not...haha |