Favorite Podcast???

Don't get me started..I am a podcast addict! OK, my favorite one right now is SModcast. Kevin Smith and Scott Mosier sitting around for an hour cracking jokes and talking about nothing. It's freaking hilarious. I have had to turn it off while listening to it in waiting rooms and airplanes because I was laughing so hard I was crying, which looks strange when you are sitting in an airplane or in a waiting room.
Science: two that I really enjoy are The Naked Scientist and Radio Lab. Radio Lab is by far my favorite podcast of any genre. Every episode is amazing and wonderfully produced.
Music: All Songs Considered. Indie Feed (pick a genre).
Human Interest...Of course you must listen to This American Life. My favorite episode of all time is the one from a few years back with the Reverend Carlton Pearson (his story for me is about the personalities that make good leaders and he has SUCH a dynamic personality). Also, Dan Carlin's Hard Core History is pretty good. I have recently started listening to Philosophy Bites, which is dry but short so I can maintain my attention if I try hard enough. They had an interesting episode on friendship recently.

x2 for This American Life. I also really like AthCast, podcasts of concerts performed by Athens, GA bands (and some other indie bands).

Right now, you can download shows by these bands for free (edit: links below don't work--visit the link above to download the podcasts):

I'm a podcast addict as well.

A second vote for SModcast. (However if you are easily offended you might want to pass). If you've seen Kevin Smith's movies you'll know what to expect.

Wait, Wait... as you know is a great one.

Car Talk can be funny at times.

Skeptic's Guide to the Universe - the poke holes in stuff like ghost sightings, perpetual motion claims, psychics, and other pseudo science

Tri related ones:

The Competitors Radio Show (interviews with triathletes)

Endurance Planet.com - daily 15 min stories or interviews

Phedippidations - running

Tri-Talk - David can get REAL technical. Overall pretty good but can get a bit dull at times.

I'm always looking for new ones as well.

X2 on All Songs Considered and Phedippitations, as well.