As a rehabilitating gun collector and former IDPA/IPSC/3-Gun competitor...I've pretty much owned and shot every pistol out there in general circulation; Beretta, SIG Sauer, Glock, Colt, Kimber, Springfield, Steyr, Ruger, Smith & Wesson, etc.
When I downsized my collection of probably 20-30 pistols, I kept only my 1911's and Glocks. I haven't looked back, or desired to own any other pistols since.
I would take a serious look at the Glock models in .40 (22/23/27). They are simple to operate, reliable, accurate, incredibly durable and corrosion resistant.
There's nothing wrong with any of the other brands mentioned above--HK's are first class, but their USP have big and blocky grips for me--its just that a Glock IMO makes a pistol to fit just about any individual's self-defense requirements without breaking the bank.
I don't recall if its been mentioned, but get yourself some first class training. Then, practice with a purpose and regularly.
Invest in a combat-type flashlight (i.e. Surefire, Gladius, etc.) and practice shooting while clutching the light in your preferred hold. A real self-defense shooting is likely to happen in low-light. And with the axiom of never shoot at anything you can't id, you'll need to learn to apply illumination on your target.
If you're truly serious about self-defense, set aside the funds to take one of the self-defense classes (a la Gunsite). Shooting for fun is one thing, shooting under pressure or in low-light is another.
Edit: The only "pressure" I've shot under is competition (and self-defense shooting courses)--which is/are admittedly even a poor substitute for the real thing. I've never "seen the elephant" and hope never to.
Edited by guncollector 2008-05-20 6:34 PM